I just found a working solution to use Chrome to run ActiveX commands. This is done in Chrome by adding the extension IE TAB in Chrome. you can download it from: https://chrome.google.com/webstore/detail/ie-tab/hehijbfgiekmjfkfjpbkbammjbdenadd

Within Chrome you will get a button in your toolbar which adds an URL address box to your Chrome tab. In below picture I am invoking a RDP session.

UI Action Script I used for RDP (posted in another community article by Laurens Brand

function Run() {

try {

var objShell = new ActiveXObject("WScript.Shell");

objShell.Run("mstsc /v:192.168.1.254");

} catch(e) {

alert(e);

}

}